A REVIEW ON MIXED HYDROTROPY: SOLUBILITY ENHANCEMENT TECHNIQUE FOR POORLY AQUEOUS SOLUBLE DRUGS
نویسندگان
چکیده
منابع مشابه
Solubility Enhancement of Poorly Water Soluble Drugs: a Review
Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to reach market due to their poor water solubility. Drug with poor water solubility cause slow dissolution rates, generally show erratic and incomplete absorption leading to low bioavailability when administered orally. Aqueous solubility of any therapeutically active substance is a key property, as it governs...
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In the preformulation study physical compatibility of the drug-excipient was screened and compatibility was observed between Zaltoprofen and selected solubilizers. In the drug solubilizers interference study no interference was observed in UV spectrophometric analysis of Zaltoprofen in presence of employed solubilizers. Aqueous solubility of Zaltoprofen was found 0.028 mg/ml. The solubilizers s...
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Solid dispersions have been employed to enhance the dissolution rates of poorly water-soluble drugs. Many approaches have been investigated for the preparation of solid dispersions. This paper reports the various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, e...
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A target of best dissolution improvement of poorly soluble drugs is a necessity for the success of formulation in industry. The present work describes the preparation, optimization, and evaluation of a new spherical agglomeration technique for glimepiride as a model of poorly soluble drugs. It involved the emulsification of a drug solution containing a dispersed carrier that tailors the crystal...
متن کاملA New Crystal Engineering Technique for Dissolution Enhancement of Poorly Soluble Drugs Combining Quasi-emulsion and Crystallo-co Agglomeration Methods
A target of best dissolution improvement of poorly soluble drugs is a necessity for the success of formulation in industry. The present work describes the preparation, optimization, and evaluation of a new spherical agglomeration technique for glimepiride as a model of poorly soluble drugs. It involved the emulsification of a drug solution containing a dispersed carrier that tailors the crystal...
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ژورنال
عنوان ژورنال: International Research Journal Of Pharmacy
سال: 2020
ISSN: 2230-8407
DOI: 10.7897/2230-8407.110976